Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias.
PURPOSE The purpose of our study was to investigate the pharmacology of clofarabine and its triphosphate and the pharmacodynamic actions in circulating blasts obtained from acute leukemia patients who entered a Phase I clinical trial of clofarabine. EXPERIMENTAL DESIGN Adults with refractory acute leukemias including lymphoblastic (ALL), myelogenous (AML) and chronic myelogenous leukemia in b...
متن کاملPlasma and cerebrospinal fluid pharmacokinetics of clofarabine in nonhuman primates.
INTRODUCTION Clofarabine (2-chloro-2'fluoro-2'-deoxy-9-beta-d-arabinofuranosyladenine) is a purine nucleoside analogue that is active in the treatment of acute leukemia. We studied the pharmacokinetics and cerebrospinal fluid penetration of clofarabine in a nonhuman primate model. METHODS A dose of 2.3 mg/kg of clofarabine was given i.v. over 2 hours to each of four animals. Plasma and cerebr...
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ژورنال
عنوان ژورنال: The Kaohsiung Journal of Medical Sciences
سال: 2016
ISSN: 1607-551X
DOI: 10.1016/j.kjms.2016.04.001